Protective Role for Myeloid Specific KLF2 in Atherosclerosis

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective role for myeloid specific KLF2 in atherosclerosis.

Chronic inflammatory diseases, such as atherosclerosis, are associated with imbalanced recruitment of monocytes and neutrophils to the impaired tissue. Neutrophils are among the first cells detected in developing atherosclerotic plaque. As early as in fatty streaks, monocytes enter the nascent lesions and can differentiate into macrophages.2 Lineage and microenvironmental stimuli determine the ...

متن کامل

Protective role of interleukin-10 in atherosclerosis.

The potential role of anti-inflammatory cytokines in the modulation of the atherosclerotic process remains unknown. Interleukin (IL)-10 has potent deactivating properties in macrophages and T cells and modulates many cellular processes that may interfere with the development and stability of the atherosclerotic plaque. IL-10 is expressed in human atherosclerosis and is associated with decreased...

متن کامل

Protective role of imatinib in atherosclerosis.

The “metabolic syndrome,” also known as the insulin resistance syndrome or syndrome X, provides an effective framework for investigating the increased cardiovascular risk factors and adverse events related to atherosclerosis.1–3 Metabolic syndrome includes obesity, hypertension, dyslipidemia, and impaired glucose tolerance. An increasing body of evidence in both human and mouse studies now sugg...

متن کامل

Protective Role for Properdin in Progression of Experimental Murine Atherosclerosis

Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride synthesis. Deficiency of Factor B of the alternative pathway (AP) of complement is beneficial in LDLR(-/-) mice fed a high fat diet. The serum glyco...

متن کامل

The specific role of chemokines in atherosclerosis.

Atherosclerosis is a chronic inflammatory disease that represents the primary cause of heart disease and stroke. The recruitment of inflammatory cells in the intima is an essential step in the development and progression of atherosclerosis. This process is triggered by local production of chemokines and chemokine receptors from activated endothelial cells and inflammatory cells. Various members...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Circulation Research

سال: 2012

ISSN: 0009-7330,1524-4571

DOI: 10.1161/circresaha.112.270991